학력

• 1994-1998 서울시립대학교 생명과학과, 이학사
• 1998-2000 서울대학교 분자생물학과, 이학석사
• 2003-2007 전남대학교 의과대학, 의학박사

경력

• 2007. 10 - 2011. 11 University of Colorado Denver, School of Medicine, Postdoctoral Fellow
• 2011. 12 - 2017. 5 Massachusetts Institute of Technology, Research Associate
• 2017. 6 - 2018. 8  Chonnam National University Medical School, 연구교수
• 2018 - 한국외국어대학교 생명공학과 조교수/부교수
• 2019 - 한국미생물생명공학회 간사
• 2020 - 2021 한국미생물학회 실무위원
• 2020 - 대한미생물학회 편집위원

Research Interests

Our research focuses on synthetic biology. We are exploring new applications of microorganisms as platforms for personalized medicine, screening systems for valuable biological molecules, and tools for modulating functions in plants. Additionally, we are investigating the molecular mechanisms underlying infectious diseases caused by Gram-negative pathogens, such as Salmonella, pathogenic E. coli species, and Acinetobacter baumannii. Consequently, our findings are being integrated into the design of engineered bacteria for disease treatment, including various cancers and biological therapeutics.

최근 논문

• Hong HW, Jang J, Kim YD, Jeong TH, Lee D, Park K, Kim MS, Yoon IS, Song M, Seo MD, Yoon H, Lim D, Myung H. In vitro and in vivo efficacy studies of an engineered endolysin targeting Gram-negative pathogens. Int J Biol Macromol. 302:140463 (2025)
• Jeon HJ, Lim D, So E, Kim S, Jeong JH, Song M*, Lee HJ*, Controlling tumor progression and recurrence in mice through combined treatment with a PD-L1 inhibitor and a designer Salmonella strain that delivers GM-CSF, Acta Pharmaceutica Sinica B, 14:5479 (2024) *co-corresponding author
• Lim J, Myung H, Lim D*, Song M*, Antimicrobial peptide thanatin fused endolysin PA90 (Tha-PA90) for the control of Acinetobacter baumannii infection in mouse model. J. Biomed. Sci, 31:36 (2024) *co-corresponding author
• Mai PT, Lim D, So E, Kim HY, Duysak T, Tran TQ, Song M, Jeong JH, Choy HE, Constitutive e-x-p-r-e-s-s-i-o-n of a Cytotoxic Anticancer Protein in Tumor-Colonizing Bacteria. Cancers (Basel), 15:1486 (2023).
• Jeong T-H., Hong H-W, Kim MS, Song, M, Myung H, Characterization of Three Different Endolysins Effective against Gram-Negative Bacteria. Viruses, 15: 679 (2023).
• Lim J, Hong J, Jung Y, Ha J, Kim H, Myung H, Song M, Bactericidal Effect of Cecropin A Fused Endolysin on Drug-Resistant Gram-Negative Pathogens. J Microbiol Biotechnol, 32:816 (2022).
• Lim J, Jang J, Myung H, Song M, Eradication of drug-resistant Acinetobacter baumannii by cell-penetrating peptide fused endolysin. J Microbiol 60: 859 (2022).
• Lim D, Park SJ, Kim HY, Shin M, Song M, Lipocalin2 as a potential antibacterial drug against Acinetobacter baumannii infection. J Microbiol, 60:444 (2022)
• Hong H-W, Kim YD, Jang J, Kim MS, Song M and Myung H, Combination Effect of Engineered Endolysin EC340 With Antibiotics. Front Microbiol, 13:821936 (2022)
• Nguyen DH, You SH, Vo AN, Ngo HT, Van Nguyen K, Duong MT, Choy HE, Song M, Hong Y, Min JJ, Optimized Doxycycline-Inducible Gene e-x-p-r-e-s-s-i-o-n System for Genetic Programming of Tumor-Targeting Bacteria. Mol Imaging Biol, 24:82 (2022)
• Lim D, Jung Wch, Jeong JH, Song M, Targeted Delivery of the Mitochondrial Target Domain of Noxa to Tumor Tissue via Synthetic Secretion System in E. coli, Front Bioeng Biotechnol, 8: 840 (2020)
• Lim D, Kim K, Song M, et. al., Transcriptional regulation of Salmochelin glucosyltransferase by Fur in Salmonella, BBRC, 529: 70-76 (2020)
• Lim D, Kim HK, Jeong JH, Jung YS, Lee SE, Jang HC, Jung SI, Choi HS, Rhee JH, Lee SG, Park C, Song M*, Choy HE*, Lipocalin2 Induced by Bacterial Flagellin Protects Mice against Cyclophosphamide Mediated Neutropenic Sepsis, Microorganisms, 8: 646 (2020)
• Lim D and Song M, Development of bacteria as diagnostics and therapeutics by genetic engineering, J Microbiol, 57: 637-643 (2019)
• Lim D, Kim KS, Jeong JH, Marques O, Kim HJ, Song M et. al., The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages, Nat Commun, 9:2091 (2018)
• Song M et. al., Control of type III protein secretion using a minimal genetic system, Nat Commun, 8:14737 (2017)
• Fernandez-Rodriguez J+, Felix M+, Song M, Voigt CA, Engineering RBG color vision into Escherichia coli, Nat Chem Biol, 13:706-708 (2017) +co-author