학력

• 2003 한국외국어대학교 생명공학과, 이학사
• 2005 한국외국어대학교 생명공학과, 이학석사
• 2010 한국외국어대학교 생명공학과, 이학박사

주요 경력

• 2011 - 2016 Children’s Hospital of Philadelphia, Postdoctoral Fellow
• 2016 - 2019 Children’s Hospital of Philadelphia, Research Associate
• 2019 - 2020 Temple University, Associate Scientist
• 2020 - 2021 Thomas Jefferson University, Senior Research Investigator
• 2021- 2023 Children’s Hospital of Philadelphia, Research Associate
• 2023 - 현재 한국외국어대학교 생명공학과, 조교수

Research Interests

• 사람 혈액 줄기세포를 (CD34⁺ Hematopoietic Stem Cell) 이용한 유전자 결함 분화 모델 구축
• 전사조절 유전자인 RUNX1( Runt-related transcription factor-1)의 결핍에 따른 유전질환 연구
• 혈액 줄기 세포의 분화 이상에 의한 백혈병 발생 기전 및 치료제 개발 연구

최근 논문

• H Kim, D Jarocha, I Johnson, H Ahn, N Hlinka, DFrench, L Rauova, K Lee*, and M Poncz (2024) Studies of infused megakaryocytes into mice support a “catch-and-release” model of pulmonary-centric thrombopoiesis. *corresponding author. Under Revision at Blood.
• F Del Carpio-Cano, G Mao, LE Goldfinger, J Wurtzel, L Guan, MA Alam, K Lee, M Poncz, AK Rao (2024) Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency. Blood Adv. 9;8(7):1699-1714.
• K Lee and M Poncz (2023) SLFN14 ribosomopathy and platelet dysfunction. Blood. 141:2170-2172.
• M Vermunt, Z Zhe, J Luan, A Huang, J Thrasher, S Zhang, P Vemulamada, M Brilleman, K Lee, J Yano, B Giardine, C Keller, R Hardison, and G Blobel (2023) Gene silencing dynamics are modulated by transiently active regulatory elements. Molecular Cell. 83:715-730.
• K Lee, H Ahn, B Estevez, and M Poncz (2023) RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects in an in vivo murine model: Therapeutic implications. Blood 141:260-270.
• J Zhang, P Guo, X Yu, K Lee, J Firrman, M Chrzanowski, K Chen, X Chen, D Pouchnik, Y Diao, R Samulski, W Xiao (2020) Satellite sub-genomic particles are key regulators of adeno-associated virus life cycle. bioRxiv.
• C Chen, W Yu, J Tober, P Gao, B He, K Lee, T Trieu, G Blobel, N Speck, and K Tan (2019) Spatial genome re-organization between fetal and adult hematopoietic stem cells. Cell Reports 29:4200-4211.
• K Lee and G Blobel (2016) Chromatin architecture underpinning transcription elongation. Nucleus 7:1-8.
• K Lee, C Hsiung, P Huang, A Raj, and G Blobel (2015) Dynamic enhancer-gene body contacts during transcription elongation. Genes and Development 29:1992-1997.
• K Lee, J Kim, and H Kwon (2015) The actin-related protein BAF53 is essential for chromosomal subdomain integrity. Molecules and Cells 38:789-795.
• J Lim, K Lee, J Choi, H Kin, Y Hwang, W Seo, Y Won, S Kim, H Kwon, and S Huh (2012) Intracellular protein delivery by hollow mesoporous silica capsules with a large surface hole. Nanotechnology 23:085101.
• K Lee, A Lee, and H Kwon (2012) Restoration of p53 by BAF53 knockdown in human cervical cells. Biochem. Biophys. Res. Commun. 412:328-333.
• G Kim, K Lee, H Kwon, and H Kim (2011) Ratiometric fluorescence imaging of cellular glutathione. Organic Letters 13:2799-27801.
• H Kwon, K Lee, and H Kim (2011) Coumarin-malonitrile conjugate as a fluorescence turn-on probe for biothiols and its cellular e-x-p-r-e-s-s-i-o-n. Chemical Communications 47:1773-1775.
• H Park, K Lee, H Heo, M Lee, J Kim, W Whang, Y Kwon, and H Kwon (2008) Effects of Polygala tenuifolia root extract on proliferation of neural stem cells in the hippocampal CA1 region. Phytotherapy Research 22:1324-1329.
• K Lee, J Shim, M Kang, J Kim, J Ahn, S Yoo, Y Kwon, and H Kwon (2007) Association of BAF53 with Mitotic Chromosomes. Molecules and Cells 24: 288-293.
• K Lee, M Kang, S Kwon, Y Kwon, K Kim, J Lim, and H Kwon (2007) Expansion of Chromosome Territories with Chromatin Decompaction in BAF53-depleted Interphase Cells. Molecular Biology of the Cell 18: 4013-4023. (Highlighted on InCyte)