세부내용
학력
- 2003 한국외국어대학교 생명공학과, 이학사
- 2005 한국외국어대학교 생명공학과, 이학석사
- 2010 한국외국어대학교 생명공학과, 이학박사
주요 경력
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2011 - 2016 Children’s Hospital of Philadelphia, Postdoctoral Fellow
- 2016 - 2019 Children’s Hospital of Philadelphia, Research Associate
- 2019 - 2020 Temple University, Associate Scientist
- 2020 - 2021 Thomas Jefferson University, Senior Research Investigator
- 2021- 2023 Children’s Hospital of Philadelphia, Research Associate
- 2023 - 현재 한국외국어대학교 생명공학과, 부교수
Research Interests
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사람 혈액 줄기세포 (Hematopoietic Stem Cell) 및 induced Pluripotent Stem Cells (iPSCs)를 이용한 유전자 결함 분화 모델 구축
- 전사조절 유전자인 RUNX1( Runt-related transcription factor-1)의 결핍에 따른 유전질환 연구
- 혈액 줄기 세포의 분화 이상에 의한 백혈병 발생 기전 및 치료제 개발 연구
최근 논문
Lead author
- H Kim, D Jarocha, I Johnson, H Ahn, N Hlinka, DFrench, L Rauova, K Lee*, and M Poncz (2025) Studies of infused megakaryocytes into mice support a “catch-and-release” model of pulmonary-centric thrombopoiesis. *corresponding author. Under Revision at Blood.
- F Del Carpio-Cano, N Songdej, L Guan, G Mao, LE Goldfinger, JGT Wurtzel, K Lee, MP Lambert, M Poncz, AK Rao. (2025) Transcription Factor RUNX1 Regulates Coagulation Factor XIII-A (F13A1): Decreased Platelet-Megakaryocyte F13A1 e-x-p-r-e-s-s-i-o-n and Clot Contraction in RUNX1 Haplodeficiency. Res Pract Thromb Haemost. 16;9(1):102680.
- F Del Carpio-Cano, G Mao, LE Goldfinger, J Wurtzel, L Guan, MA Alam, K Lee, M Poncz, AK Rao (2024) Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency. Blood Adv. 9;8(7):1699-1714.
- K Lee and M Poncz (2023) SLFN14 ribosomopathy and platelet dysfunction. Blood. 141:2170-2172.
- M Vermunt, Z Zhe, J Luan, A Huang, J Thrasher, S Zhang, P Vemulamada, M Brilleman, K Lee, J Yano, B Giardine, C Keller, R Hardison, and G Blobel (2023) Gene silencing dynamics are modulated by transiently active regulatory elements. Molecular Cell. 83:715-730
- K Lee, H Ahn, B Estevez, and M Poncz (2023) RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects in an in vivo murine model: Therapeutic implications. Blood 141:260-270.
- C Chen, W Yu, J Tober, P Gao, B He, K Lee, T Trieu, G Blobel, N Speck, and K Tan (2019) Spatial genome re-organization between fetal and adult hematopoietic stem cells. Cell Reports 29:4200-4211.
- K Lee and G Blobel (2016) Chromatin architecture underpinning transcription elongation. Nucleus 7:1-8.
- K Lee, C Hsiung, P Huang, A Raj, and G Blobel (2015) Dynamic enhancer-gene body contacts during transcription elongation. Genes and Development 29:1992-1997.
- K Lee, J Kim, and H Kwon (2015) The actin-related protein BAF53 is essential for chromosomal subdomain integrity. Molecules and Cells 38:789-795.
- J Lim, K Lee, J Choi, H Kin, Y Hwang, W Seo, Y Won, S Kim, H Kwon, and S Huh (2012) Intracellular protein delivery by hollow mesoporous silica capsules with a large surface hole. Nanotechnology 23:085101.
- K Lee, A Lee, and H Kwon (2012) Restoration of p53 by BAF53 knockdown in human cervical cells. Biochem. Biophys. Res. Commun. 412:328-333.
- G Kim, K Lee, H Kwon, and H Kim (2011) Ratiometric fluorescence imaging of cellular glutathione. Organic Letters 13:2799-27801.
- H Kwon, K Lee, and H Kim (2011) Coumarin-malonitrile conjugate as a fluorescence turn-on probe for biothiols and its cellular e-x-p-r-e-s-s-i-o-n. Chemical Communications 47:1773-1775.
- H Park, K Lee, H Heo, M Lee, J Kim, W Whang, Y Kwon, and H Kwon (2008) Effects of Polygala tenuifolia root extract on proliferation of neural stem cells in the hippocampal CA1 region. Phytotherapy Research 22:1324-1329.
- K Lee, J Shim, M Kang, J Kim, J Ahn, S Yoo, Y Kwon, and H Kwon (2007) Association of BAF53 with Mitotic Chromosomes. Molecules and Cells 24: 288-293.
- K Lee, M Kang, S Kwon, Y Kwon, K Kim, J Lim, and H Kwon (2007) Expansion of Chromosome Territories with Chromatin Decompaction in BAF53-depleted Interphase Cells. Molecular Biology of the Cell 18: 4013-4023. (Highlighted on InCyte)
Grant
- 2025~2030 한국연구재단 우수신진연구 과제 선정